abstract：:Treatment of neonatal animals with capsaicin has previously been associated with long-lasting hyperthermia and severe cutaneous lesions. The present study analyzed the effects of capsaicin-induced hyperthermia on the occurrence of infectious disease and pruritic dermatitis in a rat model. Pregnant Sprague-Dawley (SD) ...

journal_title：Experimental and therapeutic medicine

authors： Jeong KY,Kim HM

更新日期：2015-12-01 00:00:00

abstract：:In the present study, we demonstrate that the degeneration of intervertebral discs is caused by ageing and apoptosis of matrix cells. Apoptosis is as essential as the function of proteoglycan synthesis in assessing the possible degeneration of intervertebral discs; paeoniflorin (PF) induces cytoprotective effects on v...

journal_title：Experimental and therapeutic medicine

authors： Chen SQ,Lin JP,Zheng QK,Chen SJ,Li M,Lin XZ,Wang SZ

更新日期：2015-12-01 00:00:00

abstract：:CGA-N46 is a novel antifungal peptide derived from the N-terminus of human Chromogranin A, corresponding to the 31st to 76th amino acids. Further research on its activities and characteristics may be helpful for the application of CGA-N46 in medical or other situations. In the present study, the antifungal spectrum an...

journal_title：Experimental and therapeutic medicine

authors： Li RF,Lu YL,Lu YB,Zhang HR,Huang L,Yin Y,Zhang L,Liu S,Lu Z,Sun Y

更新日期：2015-12-01 00:00:00

abstract：:Pilocytic astrocytoma (PA) is a rare glioma, which generally occurs in children and young adults. In adult patients, the majority of PA tumors are supratentorial. Due to the low morbidity rate of the disease in adults, PA is frequently misdiagnosed and mistreated. In the present study, this rare disease was successful...

journal_title：Experimental and therapeutic medicine

authors： Zhao Y,Feng L,Wei Q,Gao L

更新日期：2015-12-01 00:00:00

abstract：:The aim of the present study was to determine the function of human amniotic epithelial cell transplantation (hAECT) in promoting the healing of rats with stage III pressure ulcer (PU) and to initially investigate its possible mechanisms. A total of 96 Sprague Dawley rats were allocated at random into the model, hAECT...

journal_title：Experimental and therapeutic medicine

authors： Zhou A,Zheng X,Yu L,Quan M,Shao X,Jiang Z

更新日期：2015-12-01 00:00:00

abstract：:A clinical requirement exists for early biomarkers that can predict the severity of acute pancreatitis (AP). In order to determine whether E-cadherin is associated with the severity of AP, a pancreatitic rat model was established and the expression levels of E-cadherin were detected. A study population of 24 Sprague D...

journal_title：Experimental and therapeutic medicine

authors： Yuan W,Pan QI,Chen G,Yan J,Xia J,Chen Y

更新日期：2015-12-01 00:00:00

abstract：:The aim of this study was to investigate the surgical methods and efficacies for cervicothoracolumbar spinal schwannoma (CSS). A total of 52 patients who had undergone treatment for schwannoma were retrospectively analyzed. Two methods were employed for the surgical resection of the thoracic and lumbar schwannomas: Ty...

journal_title：Experimental and therapeutic medicine

authors： Deng Q,Tian Z,Sheng W,Guo H,Dan ME

更新日期：2015-12-01 00:00:00

abstract：:Activated T cells rely on aerobic glycolysis and glutaminolysis in order to proliferate and differentiate into effector cells. Therefore, intervention in these metabolic pathways inhibits proliferation. The aim of the present study was to evaluate the effects of Krebs' cycle inhibition at the level of malate dehydroge...

journal_title：Experimental and therapeutic medicine

authors： Eleftheriadis T,Pissas G,Antoniadi G,Liakopoulos V,Stefanidis I

更新日期：2015-11-01 00:00:00

abstract：:The aim of the present study was to examine whether the expression of focal adhesion kinase (FAK) is altered in the eutopic endometrium of female patients with adenomyosis, as compared with that of females without adenomyosis. The expression of FAK was assessed by immunohistochemical, western blot and reverse transcri...

journal_title：Experimental and therapeutic medicine

authors： Mu L,Chen W,Ma Y,Zheng W

更新日期：2015-11-01 00:00:00

abstract：:Previous studies have demonstrated that Hedyotis diffusa Willd (HDW), a traditional Chinese herbal medicine, exhibits potent anticancer activity in models of colorectal cancer (CRC). Aggressive forms of CRC exhibit resistance to widely used chemotherapeutic drugs, including the antimetabolite, 5-fluorouracil (5-FU); h...

journal_title：Experimental and therapeutic medicine

authors： Li Q,Wang X,Shen A,Zhang Y,Chen Y,Sferra TJ,Lin J,Peng J

更新日期：2015-11-01 00:00:00

abstract：:Intactable epilepsy (IE) is relatively common in pediatric epilepsy. The resistance mechanism of IE has been previously investigated. Multidrug-resistant associated protein 1 (MRP1) and MRP2 are associated with drug transport. The aim of the present study was to investigate the expression of MRP1 and MRP2 in periphera...

journal_title：Experimental and therapeutic medicine

authors： Liu X,Yue X,Chen S,Chen J,Li R

更新日期：2015-11-01 00:00:00

abstract：:Choroidal neovascularization secondary to retinitis pigmentosa is rarely observed in clinical practice. The present study describes a case of atypical retinitis pigmentosa, crystalline retinal pigmentary degeneration, complicated by choroidal neovascularization (CNV) in a 26-year-old man presenting with blurred vision...

journal_title：Experimental and therapeutic medicine

authors： Hua R,Chen K,Hu Y,Wang X,Chen L

更新日期：2015-11-01 00:00:00

abstract：:The use of intravenous dexmedetomidine during surgery has been shown to suppress inflammatory cytokines peri-operatively. It has also been demonstrated that dexmedetomidine may benefit cognitive function in elderly patients following surgery; however, it is not clear whether dexmedetomidine reduces postoperative cogni...

journal_title：Experimental and therapeutic medicine

authors： Li Y,He R,Chen S,Qu Y

更新日期：2015-11-01 00:00:00

abstract：:Tenosynovial chondromatosis is an extra-articular version of articular synovial chondromatosis and a relatively rare condition that can affect the tendon sheath, bursa, or joint synovial tissue. Tenosynovial chondromatosis is rarely reported in the literature and is often misdiagnosed. In the present study, a case of ...

journal_title：Experimental and therapeutic medicine

authors： Chen YX,Lu YX,Zhuang ZE,Li ZY

更新日期：2015-10-01 00:00:00

abstract：:Scabies is a contagious skin disease that causes extremely itching. It is a parasitic disease caused by the mite Sarcoptes scabiei and characterized by polymorphous lesions. Vesicular and bullous lesions in cases of scabies are rather rare. Bullous scabies has a pemphigoid presentation. Crusted scabies, also known as ...

journal_title：Experimental and therapeutic medicine

authors： Su WJ,Fang S,Chen AJ,Shan K

更新日期：2015-10-01 00:00:00

abstract：:Chronic myelogenous leukemia (CML) is a condition characterized by a balanced genetic translocation, t (9;22) (q34;q11.2), which leads to a fusion of the Abelson oncogene (ABL) from chromosome 9q34 with the breakpoint cluster region (BCR) gene on chromosome 22q11.2. This rearrangement is referred to as the Philadelphi...

journal_title：Experimental and therapeutic medicine

authors： Shen X,Zhang M,Shen Y,Shi W,Liu W,Wei WU

更新日期：2015-10-01 00:00:00

abstract：:Anti-mitochondrial M2 antibody (AMA-M2) is specific to primary biliary cirrhosis (PBC), but can also be found in certain patients with autoimmune hepatitis (AIH). Effective methods of differentiating between PBC and AIH are required, as their clinical course and management are different. Titers of AMA-M2 were analyzed...

journal_title：Experimental and therapeutic medicine

authors： Tomizawa M,Shinozaki F,Fugo K,Motoyoshi Y,Sugiyama T,Yamamoto S,Kishimoto T,Ishige N

更新日期：2015-10-01 00:00:00

abstract：:The aim of the present study was to determine whether the myocardial protective function of Shenmai injection (SM) during ischemia/reperfusion (I/R) is attributable to its regulation of intracellular calcium (Ca2+) and phospholamban (PLB) levels. Cultured neonatal Sprague Dawley rat cardiomyocytes were used to compare...

journal_title：Experimental and therapeutic medicine

authors： Ye LF,Zheng YR,Wang LH

更新日期：2015-10-01 00:00:00

abstract：:Nitrogen mustards are chemical agents that are similar to sulfur mustards, with similar toxicities. The present study describes a case of nitrogen mustard-induced acute respiratory failure and myelosuppression in a 33-year-old man. The patient, who was accidentally exposed to nitrogen mustard hydrochloride in a pharma...

journal_title：Experimental and therapeutic medicine

authors： Zhang X,Zhang Z,Chen S,Zhao D,Zhang F,Hu Z,Xiao F,Ma X

更新日期：2015-10-01 00:00:00

abstract：:The aim of the present study was to investigate the role and mechanism of vascular cell adhesion molecule-1 (VCAM-1) in the development of rheumatoid arthritis (RA). One hundred and twenty patients with RA who had been admitted to the Huaihe Hospital of Henan University between January and December 2013 were enrolled ...

journal_title：Experimental and therapeutic medicine

authors： Wang L,Ding Y,Guo X,Zhao Q

更新日期：2015-09-01 00:00:00

abstract：:The aim of the present study was to investigate the correlation between the protein expression of A-kinase anchor protein 95 (AKAP95), cyclin D3 and AKT with pathological indicators in lung cancer tissues. Immunohistochemistry was used to detect the protein expression levels of the proteins in 51 lung cancer tissue sa...

journal_title：Experimental and therapeutic medicine

authors： Yu X,Yuan Y,Zhi X,Teng B,Chen X,Huang Q,Chen Y,Guan Z,Zhang Y

更新日期：2015-09-01 00:00:00

abstract：:The aim of the present study was to evaluate the clinical efficacy and safety of intravitreal ranibizumab injections for the treatment of macular choroidal neovascularization (CNV) caused by pathological myopia. Between one and four intravitreal injections of ranibizumab were administered to 61 eyes from 61 patients w...

journal_title：Experimental and therapeutic medicine

authors： Ji L,Lv W,Xiao Y,Xu Z,Zhang X,Zhang W

更新日期：2015-09-01 00:00:00

abstract：:The aim of the present study was to identify a natural product with the ability to inhibit nuclear factor of activated T cells c1 (NFATc1) translocation from the cytoplasm to the nucleus by high-throughput screening, and to investigate the effect of the natural product upon osteoclast differentiation and its underlyin...

journal_title：Experimental and therapeutic medicine

authors： Geng X,Yang L,Zhang C,Qin H,Liang Q

更新日期：2015-09-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) with variant translocations is rare. The patient of the present case report, a 2-year-old male with a microgranular variant of APL carrying der(17) ins(17;15) translocation, exhibited fever and epistaxis. The complete blood count showed marked leukocytosis with 72% atypical promyeloc...

journal_title：Experimental and therapeutic medicine

authors： Guan H,Liu J,Guo X,Wu C,Yu H

更新日期：2015-09-01 00:00:00

abstract：:Monosialotetrahexosylganglioside sodium (GM1) is widely used in the treatment of central and peripheral neurological injuries. In addition to its neuroprotective activity, GM1 exerts protective effects on brain microvascular endothelial cells, although the mechanisms underlying these effects remain unclear. The aim of...

journal_title：Experimental and therapeutic medicine

authors： Zhao H,Li X,Li G,Sun BO,Ren L,Zhao C

更新日期：2015-09-01 00:00:00

abstract：:Endostatin (ES) is an endogenous angiogenesis inhibitor that has the ability to inhibit tumor growth and metastasis. However, its clinical application is limited by a number of disadvantages, such as poor stability, short half-life and the requirement of high doses to maintain its efficacy. The chemical modification o...

journal_title：Experimental and therapeutic medicine

authors： Li ZN,Yuan ZF,Mu GY,Hu M,Cao LJ,Zhang YL,Ge MX

更新日期：2015-09-01 00:00:00

abstract：:The excessive production of inflammatory cytokines during invasive infection primarily mediates the pathophysiology of sepsis. To improve the survival of septic patients, many selective or mediator-specific anti-inflammatory agents have been developed. Saikosaponin A (SsA), a triterpenoid saponin isolated from Radix B...

journal_title：Experimental and therapeutic medicine

authors： Zhao H,Li S,Zhang H,Wang G,Xu G,Zhang H

更新日期：2015-08-01 00:00:00

abstract：:Salivary gland malignant neoplasms (SGMNs) represent a group of malignant solid tumors with heterogeneity in their cellular make-up, which causes difficulty with regard to the immunohistochemical confirmation of their cytological features. In the present study, overexpression of the pituitary tumor transforming gene (...

journal_title：Experimental and therapeutic medicine

authors： Liu J,Wang Y,He H,Jin W,Zheng R

更新日期：2015-08-01 00:00:00

abstract：:The aim of this study was to use proteomic and transcriptomic approaches to examine differences in protein and gene expression in maternal plasma between normal and preeclamptic pregnancies. Preeclampsia and control groups were compared with respect to the expression of CD34 and CD133 genes by quantitative polymerase ...

journal_title：Experimental and therapeutic medicine

authors： Sahin H,Gunel T,Benian A,Onay Ucar E,Guralp O,Kilic A

更新日期：2015-08-01 00:00:00

abstract：:The aim of the present study was to investigate the effect of γ-aminobutyric acid transporter-1 (GAT-1) on the anxiety-like behaviors and cognitive function in knockout mice. In total, 20 adult male mice were divided into two groups, namely the GAT-1 knockout (GAT-1-/-) and wild-type (WT) groups. The open field test, ...

journal_title：Experimental and therapeutic medicine

authors： Gong X,Shao Y,Li B,Chen L,Wang C,Chen Y

更新日期：2015-08-01 00:00:00

abstract：:The aim of the present study was to investigate the mucus secretion status of mature goblet cells following the application of mitomycin-C (MMC) in ileal neobladder rat models. Bladder substitution models were established in Sprague Dawley rats, which had been divided into five groups, namely the control (sham), norma...

journal_title：Experimental and therapeutic medicine

authors： Fan W,Yu Y,Shu J,Ming H,Li W,Fan Z

更新日期：2015-08-01 00:00:00

abstract：:Guillain-Barré syndrome is a type of acute inflammatory neuropathy that causes ataxia and is associated with the IgG anti-GM1 antibody. However, the pathogenic role of the IgG anti-GM1 antibody and calcium channels in neuromuscular junctions (NMJs) remains unclear. Thus, the aim of the present study was to investigate...

journal_title：Experimental and therapeutic medicine

authors： Hotta S,Nakatani Y,Kambe T,Abe K,Masuda Y,Utsumomiya I,Taguchi K

更新日期：2015-08-01 00:00:00

abstract：:This study aimed to isolate rabbit adipose-derived stem cells (ADSCs) and explore the potential of platelet-rich plasma (PRP) in the chondrogenic differentiation of ADSCs, thereby potentially providing a new approach for the repair and regeneration of cartilage injury. Rabbit ADSCs were isolated and characterized by i...

journal_title：Experimental and therapeutic medicine

authors： Tang XB,Dong PL,Wang J,Zhou HY,Zhang HX,Wang SZ

更新日期：2015-08-01 00:00:00

abstract：:Erythropoietin (EPO), a glycoprotein originally known for its important role in the stimulation of erythropoiesis, has recently been shown to have significant protective effects in animal models of kidney and intestinal ischemia-reperfusion injury (IRI). However, the mechanism underlying these protective effects remai...

journal_title：Experimental and therapeutic medicine

authors： Rong R,Xijun X

更新日期：2015-08-01 00:00:00

abstract：:The aim of the present study was to evaluate the diagnostic value of interferon-γ release assays for the detection of active tuberculosis (ATB) in patients previously vaccinated with Bacillus Calmette-Guérin (BCG). In total, 540 patients underwent the T-SPOT.TB test, including 295 patients with active pulmonary TB (PT...

journal_title：Experimental and therapeutic medicine

authors： Yan L,Xiao H,Han M,Zhang Q

更新日期：2015-07-01 00:00:00

abstract：:The objective of the study was to evaluate the effect of abdominal fat proportion on hepatic computed tomography (CT) enhancement. CT data for 87 patients (47 men, mean age 55.09±13.27 years; 40 women, mean age 60.43±11.29 years) were analyzed by linear regression to assess the association of patient age and abdominal...

journal_title：Experimental and therapeutic medicine

authors： Zhang Q,Guo MJ,Wu YF

更新日期：2015-07-01 00:00:00

abstract：:The present study evaluated the value of black-blood high-resolution magnetic resonance imaging (HRMRI) for the visualization of intracranial atherosclerosis (ICAS) plaques. A total of 110 patients with cerebral artery or vertebrobasilar stenosis, vessel occlusion or a significantly weakened signal in black-blood magn...

journal_title：Experimental and therapeutic medicine

authors： Yang H,Zhu Y,Geng Z,Li C,Zhou L,Liu QI

更新日期：2015-07-01 00:00:00

abstract：:The aim of the present study was to investigate the safety of tirofiban alone and in combination with various treatments in acute ischemic stroke (AIS). A total of 120 patients with AIS were included in the study, and these patients were divided into three treatment groups: Group A (tirofiban alone, n=68), group B (ti...

journal_title：Experimental and therapeutic medicine

authors： Zhu YQ,Zhang YJ,Ruan HL,Liu Q,Zhan Q,Li Q

更新日期：2015-07-01 00:00:00

abstract：:The purpose of the present study was to assess the effects of single-session dietary counseling on salt restriction in Japanese cardiology outpatients as assessed using spot urine measurements. A total of 72 patients (73±11 years old, including 30 females) who visited a cardiology outpatient clinic and had a salt inta...

journal_title：Experimental and therapeutic medicine

authors： Yamasaki T,Sadanaga T,Hirota S

更新日期：2015-07-01 00:00:00

abstract：:In vitro differentiation of human embryonic stem cells (hESCs) into endometrium-like cells may provide a useful tool for clinical treatment. The aim of the present study was to investigate the differentiation potential of hESCs into endometrium-like cells using three methods, which included induction by feeder cells, ...

journal_title：Experimental and therapeutic medicine

authors： Yu W,Niu W,Wang S,Chen X,Sun BO,Wang F,Sun Y

更新日期：2015-07-01 00:00:00